Quartet was founded based on groundbreaking scientific observations from scientists at Boston Children’s Hospital and École Polytechnique Fédérale de Lausanne (EPFL) linking the tetrahydrobiopterin (BH4) synthesis pathway to chronic pain and inflammation. Quartet is positioned as a world leader in uncovering the role that increased levels BH4 plays in human disease biology and developing therapies to safely reduce elevated BH4 levels.